Andrew Woehler

Sep 21, 2023 | nature.com | Ivano Legnini |Agnieszka Rybak-Wolf |Ricardo Wurmus |Anastasiya Boltengagen |Stefan Kempa |Andrew Woehler | +3 more

AbstractOrganoids derived from stem cells have become an increasingly important tool for studying human development and modeling disease. However, methods are still needed to control and study spatiotemporal patterns of gene expression in organoids. Here we combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns.

Jun 22, 2023 | nature.com | Agnieszka Rybak-Wolf |Emanuel Wyler |Ivano Legnini |Seung Joon Kim |Benedikt B. Kaufer |Andrew Woehler | +2 more

Study designIn this study, we used human cerebral organoids as a model for acute HSV-1. The aim of the study was as follows: (1) to assess cellular and molecular signatures associated with viral infection; (2) to study the outcome of the current antiviral therapy used in clinical practice (ACV); (3) to identify and test better potential therapeutic approaches based on the results of 1 and 2.