Richard A. Spritz

Oct 16, 2024 | cell.com | Richard A. Spritz

Key wordsvitiligoautoimmune diseasespolygenic risk scorePRSage of onsetMHC class IIheritabilityenvironmental risk factorsGet full text accessLog in, subscribe or purchase for full access. References2. Roberts, G.H.L. ∙ Santorico, S.A. ∙ Spritz, R.A.Deep genotype imputation captures virtually all heritability of autoimmune vitiligoHum. Mol. Genet. 2020; 29:859-8633. Roberts, G.H.L. ∙ Santorico, S.A. ∙ Spritz, R.A.The genetic architecture of vitiligoPigment Cell Melanoma Res. 2020; 33:8-154.

Apr 6, 2023 | nature.com | Sahin Naqvi |Richard A. Spritz |Ophir Klein |Benedikt Hallgrímsson |Peter Claes |Jon Pritchard

AbstractTranscriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such observations requires quantitative studies of TF dosage effects at trait-relevant ranges, largely lacking so far.