Ophir Klein

Jan 8, 2025 | nature.com | Farhoud Faraji |Sydney I. Ramirez |Kuniaki Sato |Kenneth Kim |Quinton Smith |Ophir Klein

AbstractTumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ spatiotemporally controlled oncogene activation and tumor suppressor inhibition together with multiomics to unveil the processes underlying oral epithelial progenitor cell reprogramming into tumor initiating cells at single cell resolution.

Apr 9, 2024 | nature.com | Ophir Klein

AbstractStromal fibroblasts are a major stem cell niche component essential for organ formation and cancer development. Fibroblast heterogeneity, as revealed by recent advances in single-cell techniques, has raised important questions about the origin, differentiation, and function of fibroblast subtypes.

Apr 6, 2023 | nature.com | Sahin Naqvi |Richard A. Spritz |Ophir Klein |Benedikt Hallgrímsson |Peter Claes |Jon Pritchard

AbstractTranscriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such observations requires quantitative studies of TF dosage effects at trait-relevant ranges, largely lacking so far.