Richard M. Higashi

Mar 29, 2024 | nature.com | Richard M. Higashi |Andrew Lane |Jianmin Wang |Philip L McCarthy

AbstractMyeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy in a preclinical lymphoma model.

Aug 7, 2023 | nature.com | Siwen Kang |Richard M. Higashi |David Scott |Zihai Li |Jun Yang |Andrew Lane | +1 more

AbstractRobust and effective T cell immune surveillance and cancer immunotherapy require proper allocation of metabolic resources to sustain energetically costly processes, including growth and cytokine production. Here, we show that asparagine (Asn) restriction on CD8+ T cells exerted opposing effects during activation (early phase) and differentiation (late phase) following T cell activation.