Zihai Li

Feb 5, 2024 | nature.com | Xin Li |Min Fang |Zihai Li

AbstractThe maturation process of natural killer (NK) cells, which is regulated by multiple transcription factors, determines their functionality, but few checkpoints specifically targeting this process have been thoroughly studied. Here we show that NK-specific deficiency of glucose-regulated protein 94 (gp96) leads to decreased maturation of NK cells in mice.

Dec 22, 2023 | mdpi.com | Lingbin Meng |Katharine A. Collier |Peng Wang |Zihai Li

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Aug 7, 2023 | nature.com | Siwen Kang |Richard M. Higashi |David Scott |Zihai Li |Jun Yang |Andrew Lane | +1 more

AbstractRobust and effective T cell immune surveillance and cancer immunotherapy require proper allocation of metabolic resources to sustain energetically costly processes, including growth and cytokine production. Here, we show that asparagine (Asn) restriction on CD8+ T cells exerted opposing effects during activation (early phase) and differentiation (late phase) following T cell activation.