Rie Kajino-Sakamoto

Oct 6, 2023 | nature.com | Yasushi Kojima |Emi Mishiro-Sato |Teruaki Fujishita |Rie Kajino-Sakamoto |Isao Oze |Keitaro Matsuo | +1 more

AbstractCancer cachexia is a complex metabolic disorder accounting for ~20% of cancer-related deaths, yet its metabolic landscape remains unexplored. Here, we report a decrease in B vitamin-related liver enzymes as a hallmark of systemic metabolic changes occurring in cancer cachexia. Metabolomics of multiple mouse models highlights cachexia-associated reductions of niacin, vitamin B6, and a glycine-related subset of one-carbon (C1) metabolites in the liver.