-
Nov 5, 2024 | 
nature.com | Tanya J. Major |Riku Takei |Yuya Shirai |Wei Qing Wang |Murray Cadzow |Amanda Phipps-Green | +35 more
Correction to: Nature Genetics https://doi.org/10.1038/s41588-024-01921-5. Published online 15 October 2024. In the version of the article originally published, there were errors in the consortium lists at the end of the paper. Maureen Rischmueller, Hyon K. Choi, Masahiro Nakatochi, Jeff N. Miner, Daniel H. Solomon, Kathleen M. Giacomini and Deanna J. Brackman were erroneously listed as members of the Japan Gout Genomics Consortium.
-
Oct 15, 2024 | 
nature.com | Tanya J. Major |Riku Takei |Yuya Shirai |Wei Qing Wang |Murray Cadzow |Amanda Phipps-Green | +35 more
AbstractGout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of gout from a genome-wide association study (GWAS) of 2.6 million people, including 120,295 people with prevalent gout. We detected 377 loci and 410 genetically independent signals (149 previously unreported loci in urate and gout).
-
Aug 6, 2024 | 
digitalcommons.library.tmc.edu | Jianxin Shi |Kouya Shiraishi |Jiyeon Choi |Keitaro Matsuo
AbstractLung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci.
-
Feb 5, 2024 | 
nature.com | Masamitsu Yanada |Shingo Yano |Fumihiko Ishimaru |Makoto Onizuka |Keitaro Matsuo |Yoshiko Atsuta | +2 more
AbstractThis study aimed to address the prognostic impact of center experience based on the data of 7821 adults with acute myeloid leukemia who underwent allogeneic hematopoietic cell transplantation (HCT) from 2010 to 2019 in Japan, where medical care was provided within a uniform healthcare system.
-
Jan 31, 2024 | 
nature.com | Yuki Ishikawa |Nao Tanaka |Mitsuteru Akahoshi |Takashi Matsushita |Akira Oka |Motohisa Yamamoto | +15 more
AbstractHere we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region, which shows a penetrating association in the Asian population, while a complete linkage disequilibrium SNP, rs10917688, is found in a cis-regulatory element for IRF8.
-
Oct 6, 2023 | 
nature.com | Yasushi Kojima |Emi Mishiro-Sato |Teruaki Fujishita |Rie Kajino-Sakamoto |Isao Oze |Keitaro Matsuo | +1 more
AbstractCancer cachexia is a complex metabolic disorder accounting for ~20% of cancer-related deaths, yet its metabolic landscape remains unexplored. Here, we report a decrease in B vitamin-related liver enzymes as a hallmark of systemic metabolic changes occurring in cancer cachexia. Metabolomics of multiple mouse models highlights cachexia-associated reductions of niacin, vitamin B6, and a glycine-related subset of one-carbon (C1) metabolites in the liver.
-
Oct 2, 2023 | 
nature.com | Minta Thomas |Elisabeth Rosenthal |Lori C. Sakoda |Stephanie Schmit |Maria Timofeeva |Ceres Fernández-Rozadilla | +60 more
AbstractPolygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations.
-
Oct 2, 2023 | nature.com | Minta Thomas |Elisabeth Rosenthal |Lori C. Sakoda |Stephanie Schmit |Maria Timofeeva |Ceres Fernández-Rozadilla | +60 more
AbstractPolygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations.
-
Jul 12, 2023 | 
mdpi.com | Keitaro Matsuo |Masaru Tateno |Tomohiro Nakao |Ryoko Katsuki
AltmetricshareShareannouncementHelpformat_quoteCitethumb_up... Endorsetextsms... CommentNeed Help? SupportFind support for a specific problem in the support section of our website. Get SupportFeedbackPlease let us know what you think of our products and services. Give Feedback InformationVisit our dedicated information section to learn more about MDPI.
-
May 11, 2023 | 
onlinelibrary.wiley.com | Sota Kyuragi |Toshio Matsushima |Keitaro Matsuo |Tomohiro Nakao
Hikikomori, a severe form of social withdrawal, refers to the phenomenon of people who avoid social participation and remain at home for 6 months or longer.1 Previously, hikikomori was thought to be unique to Japan but hikikomori-like cases have been reported in many other countries, and it has become a growing global issue.1, 2 In 2022, “hikikomori” has been listed in the Diagnostic and Statistical Manual of Mental Disorders, Text Revision (DSM-5-TR).3 We have established the Hikikomori...
