Emi Mishiro-Sato

Dec 1, 2023 | onlinelibrary.wiley.com | Yu Li |Teruaki Fujishita |Emi Mishiro-Sato |Yasushi Kojima

4HT 4-hydroxy-tamoxifen C mice Pdgfra-CreERT2/Ctnnb1flox(ex3) mice C.casp3 cleaved caspase 3 CS mice Pdgfra-CreERT2/Ctnnb1flox(ex3)/Smad4flox/folx mice CSRP2 Cysteine-and-Glycine-Rich Protein 2 DTs desmoid tumors 1 INTRODUCTION Desmoid tumors (DTs), also known as desmoid-type fibromatoses, are soft-tissue tumors of mesenchymal origin with intermediate malignancy.1 DTs are largely sporadic (>90%) and may occur anywhere in the body, but are most frequently found in the abdominal cavity,...

Oct 6, 2023 | nature.com | Yasushi Kojima |Emi Mishiro-Sato |Teruaki Fujishita |Rie Kajino-Sakamoto |Isao Oze |Keitaro Matsuo | +1 more

AbstractCancer cachexia is a complex metabolic disorder accounting for ~20% of cancer-related deaths, yet its metabolic landscape remains unexplored. Here, we report a decrease in B vitamin-related liver enzymes as a hallmark of systemic metabolic changes occurring in cancer cachexia. Metabolomics of multiple mouse models highlights cachexia-associated reductions of niacin, vitamin B6, and a glycine-related subset of one-carbon (C1) metabolites in the liver.