Rishvanth K. Prabakar

Oct 1, 2024 | biorxiv.org | Rishvanth K. Prabakar |Michael Schmidt |Peter J. Kuhn |Peter Kühn |James Hicks

AbstractCirculating tumor cells (CTCs), and circulating tumor related cells, are extremely rare cells that intravasate from the tumor into the circulatory system and can be captured via a liquid biopsy. Although CTCs contribute to the metastatic cascade, and diverse phenotypes of CTCs have been observed - including the cytokeratin expressing CTCs, CTC clusters, large polyploid CTCs, and CTCs undergoing epithelial to mesenchymal transition - little is known about their functionality.

Aug 23, 2024 | biorxiv.org | Michael Schmidt |Rishvanth K. Prabakar |Mohamed Kamal |Amin Naghdloo

AbstractTherapeutic resistance in cancer significantly contributes to mortality, with many patients eventually experiencing recurrence after initial treatment responses. Recent studies have identified therapy-resistant large polyploid cancer cells in patient tissues, particularly in late-stage prostate cancer, linking them to advanced disease and relapse.