Ritu Sampige

Jul 30, 2024 | mdpi.com | Ritu Sampige |Joshua Ong |Ethan Waisberg |John Berdahl

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Jul 21, 2024 | nature.com | Joshua Ong |Benjamin Soares |Ethan Waisberg |Alex Suh |Ritu Sampige |Tuan Nguyen | +3 more

Human spaceflight, particularly for long-duration missions, poses significant challenges to astronaut health and well-being. Understanding the impact of spaceflight on the human body is paramount to ensuring the success and safety of such endeavours [1, 2]. In addition to the neuro-ophthalmic findings of spaceflight associated neuro-ocular syndrome (SANS), there are also effects on the anterior segment including increased risk for cataract and dry eye symptoms [3, 4].

Jul 10, 2024 | nature.com | Ritu Sampige |Joshua Ong

With increasing numbers of space travelers (professional astronauts and civilians alike), there is a need to better understand the impact of spaceflight on human health. Short and long duration spaceflight is associated with a myriad of spaceflight-associated hazards including microgravity and radiation exposure; psychological isolation and confinement; and changes to diet, sleep, circadian rhythm, and exercise [1, 2].

May 27, 2024 | nature.com | Ritu Sampige |Joshua Ong |Prithul Sarker |Alireza Tavakkoli

About 25% of astronauts after short duration spaceflight and 53% of astronauts after long duration spaceflight (LDSF) report a decline in near vision from a hyperopic refractive shift that occurs in microgravity. The refractive change is the primary visual symptom of Spaceflight Associated Neuro-Ocular Syndrome (SANS) [1, 2]. SANS encompasses a series of neuro-ocular findings seen in astronauts after LDSF [3].

May 24, 2024 | nature.com | Joshua Ong |Ritu Sampige

The chronic, low-grade inflammation that occurs with aging is termed “inflammaging,” and it is a source of age-associated illnesses across body systems [1]. Inflammaging has widespread potential adverse effects on stem cell regeneration, macromolecules, metabolism, protein homeostasis, and epigenetics, including contributing to age-related dry eye disease (DED) [1, 2].