Robert Hamilton

1 week ago | wsj.com | Robert Hamilton

She graduated from an Ivy League school, where she learned too many four-letter words. My wife and I attended a dinner at a friend’s house. I was seated next to a young lady I had never met, but I knew she was an Ivy League graduate. During our dinner chat, she managed to lace into our conversation a string of vulgarities covering the gamut of things I wasn’t allowed to say as a child. Halfway through the evening, she stopped, looked at me quizzically and asked if her language was offending me.

Aug 27, 2024 | jamanetwork.com | Robert Hamilton |Julian Chavarriaga |Cindy Y Lau |Najia Khurram

Key PointsQuestion  Is 5-alpha-reductase-inhibitor (5-ARI) use prior to prostate cancer (PCa) diagnosis associated with overall mortality or PCa-specific mortality? Findings  In this cohort study of 19 938 patients with PCa who had long-term follow-up and detailed pathological information, prediagnostic 5-ARI use was not associated with overall mortality or PCa mortality. Meaning  These findings suggest that 5-ARIs are safe to use for benign prostatic hyperplasia and PCa chemoprevention.

Jun 3, 2024 | ablawg.ca | Robert Hamilton

By: Robert HamiltonCase Commented on: Reference re An Act respecting First Nations, Inuit and Métis children, youth and families, 2024 SCC 5 (CanLII)PDF Version: Can the Federal Government Compel Provincial Authorities to Respect an Indigenous Right of Self-Government?

Nov 9, 2023 | nature.com | Thomas Sellers Jr. |David Hunter |Ian Thompson |Robert Hamilton |Ana Francisca Vega |Eric A. Klein | +98 more

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups. A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

Oct 25, 2023 | ablawg.ca | Robert Hamilton

By: Robert HamiltonCase Commented on: Reference re Impact Assessment Act, 2023 SCC 23 (CanLII) PDF Version: The IAA Reference: A Missed Opportunity for Guidance on Important Issues Pertaining to Indigenous PeoplesIn the Reference re Impact Assessment Act, 2023 SCC 23 (CanLII) (IAA Ref), the Supreme Court of Canada considered the constitutionality of the federal environmental impact assessment regime.