Ana Francisca Vega's profile photo

Ana Francisca Vega

Mexico

Journalist at MVS Noticias

periodista | politóloga | animalista | @MVSNoticias | @elpaismexico | escribí #MexicanosComoYo y #CorazónDeMexicanosComoYo | @CIDE_MX y @StAntsCollege |🇲🇽🇨🇱

Articles

  • Nov 6, 2024 | nature.com | Joan Röhl |Johanna Schleutker |Kenneth Muir |Henrik Grönberg |Nora Pashayan |Demetrius Albanes | +20 more

    AbstractGenetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity mediates prostate cancer pathogenesis.

  • Nov 9, 2023 | nature.com | Thomas Sellers Jr. |David Hunter |Ian Thompson |Robert Hamilton |Ana Francisca Vega |Eric A. Klein | +98 more

    The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups. A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

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Ana Francisca Vega 🌿
Ana Francisca Vega 🌿 @anafvega
13 May 25

RT @MVSNoticias: #AlAire 🎙️ 🏠 Este 2025 los créditos hipotecarios tendrán un crecimiento moderado 📉. Daniel Urías (@coolturafin) explica…

Ana Francisca Vega 🌿
Ana Francisca Vega 🌿 @anafvega
13 May 25

RT @MVSNoticias: #AlAire 🎙️ 🔥 México se calienta más rápido que el promedio del planeta. La Dra. Carolina Ureta, de la UNAM, explica con…

Ana Francisca Vega 🌿
Ana Francisca Vega 🌿 @anafvega
13 May 25

RT @MVSNoticias: #AlAire 🎙️ 🐄 México pierde $11.4 millones diarios por brote de gusano barrenador en Oaxaca y Veracruz. La exportación de…