Robert Hynds

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Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models - Nature Communications

May 31, 2024 | nature.com | Robert Hynds |Ariana Huebner |David Pearce |Mark Hill |Ayse U. Akarca |David Moore | +17 more

AbstractPatient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients enrolled in the TRACERx study. Multi-region tumor sampling increased successful PDX engraftment and most models were histologically similar to their parent tumor.

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