Mark Hill

Jan 9, 2025 | nature.com | Dhruva Biswas |Yun-Hsin Liu |Javier Herrero |Yin Chao Wu |David Moore |Takahiro Karasaki | +18 more

AbstractHuman tumors are diverse in their natural history and response to treatment, which in part results from genetic and transcriptomic heterogeneity. In clinical practice, single-site needle biopsies are used to sample this diversity, but cancer biomarkers may be confounded by spatiogenomic heterogeneity within individual tumors.

Jul 4, 2024 | nature.com | Alexander Frankell |Michelle Dietzen |Maise Al Bakir |Takahiro Karasaki |Sophia Ward |Emma Colliver | +25 more

Correction to: Nature https://doi.org/10.1038/s41586-023-05783-5 Published online 12 April 2023In the version of the article initially published, the symbols for death (x) and censored (>) were swapped in the graphs in Fig. 1. The figure has now been corrected in the HTML and PDF versions of the article.

May 31, 2024 | nature.com | Robert Hynds |Ariana Huebner |David Pearce |Mark Hill |Ayse U. Akarca |David Moore | +17 more

AbstractPatient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients enrolled in the TRACERx study. Multi-region tumor sampling increased successful PDX engraftment and most models were histologically similar to their parent tumor.