Robert J. Bastidas

Feb 15, 2024 | elifesciences.org | Robert J. Bastidas |Robert Davidson |Stephen Walsh |Lee Dolat

eLife assessment This important study combines state-of-the art proteomics and genetic manipulation of Chlamydia trachomatis to study the function of a chlamydial effector, Cdu1, with deubiquitination and acetylation activities.

Oct 30, 2023 | biorxiv.org | Robert J. Bastidas |Robert Davidson |Stephen Walsh |Lee Dolat

AbstractMany cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities. The obligate intracellular pathogen Chlamydia trachomatis secretes Cdu1 (ChlaDUB1), a dual deubiquitinase and Lys-acetyltransferase, that promotes Golgi remodeling and survival of infected host cells presumably by regulating the ubiquitination of host and bacterial proteins.

May 30, 2023 | pubmed.ncbi.nlm.nih.gov | Robert J. Bastidas |Raphael H. Valdivia |Bastidas RJ |Valdivia RH

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May 22, 2023 | frontiersin.org | Michael Marceau |David O'Callaghan |Sébastien Bontemps-Gallo |Robert J. Bastidas

Camille M. Riffaud, Elizabeth A. Rucks and Scot P. Ouellette*Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United StatesIn adapting to the intracellular niche, obligate intracellular bacteria usually undergo a reduction of genome size by eliminating genes not needed for intracellular survival. These losses can include, for example, genes involved in nutrient anabolic pathways or in stress response.

Feb 28, 2023 | biorxiv.org | Robert J. Bastidas |Lee Dolat |Barbara S. Sixt |Jonathan N. Pruneda

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