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3 weeks ago | 
downthetubes.net | John Freeman |Stephen Walsh |Keith Page
Fine artist Tony Galuidi is exhibiting some of his beautiful art at Brantwood, Coniston (former home of the Victorian writer, John Ruskin), and will be donating all proceeds of art sales to Knoxwood Wildlife Rescue Trust. The Victorian writer and philosopher, John Ruskin, famously described a particular view of the Lake District as “The Gateway to Paradise” – and he wasn’t wrong.
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3 weeks ago | 
downthetubes.net | John Freeman |Stephen Walsh |Keith Page
In a groundbreaking move for the global video games community, Summer Game Fest 2025 will host the first-ever Green Games Showcase, launching later this week, spotlighting the industry’s growing commitment to the environment and enabling at least 50,000 trees to be planted for habitat restoration.
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1 month ago | 
downthetubes.net | John Freeman |Stephen Walsh |Keith Page
on • Penguin Random House has signed new license agreements with Disney Publishing to publish new stories and create original content for fans of all ages based on its Marvel, Star Wars and more. The agreements extend Disney’s existing relationship with PRH, which has had a licensed program with Disney for over two decades and has handled sales and distribution for Disney’s adult and children’s print books since 2023.
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1 month ago | 
downthetubes.net | John Freeman |Stephen Walsh |Keith Page
Animation UK, in collaboration with CARTOON and with the support of BBC Children’s and Education, has announced the return of the “Animated UK Meets Europe” initiative at Cartoon Forum 2025 in Toulouse, France in September. Cartoon Forum is a pitching and co-production forum for animated TV projects. For three days, producers have the opportunity to pitch their project in front of 1000 broadcasters, investors and other potential partners from 40 countries.
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Mar 28, 2025 | 
downthetubes.net | John Freeman |Stephen Walsh |Keith Page
Peterborough Museum & Art Gallery is the current host of the long-running touring exhibition, “The Wonderful World of the Ladybird Book Artists”, a collection loaned by Helen Day, curator of the indispensable Ladybird Fly Away Home vintage book site.
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Jul 15, 2024 | 
biorxiv.org | Keith Siew |Stephen Walsh |Rebecca H. Finch |Geraldine Vitry
AbstractTo explore new worlds we must ensure humans can survive and thrive in the space environment. Incidence of kidney stones in astronauts is a major risk factor associated with long term missions, caused by increased blood calcium levels due to bone demineralisation triggered by microgravity and space radiation. Transcriptomic changes have been observed in other tissues during spaceflight, including the kidney.
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Jun 24, 2024 | 
journals.plos.org | Stephen Walsh |Cynthia L. Gay |Shelly Karuna |Ollivier Hyrien
Loading metrics Open Access Peer-reviewedResearch Article Citation: Walsh SR, Gay CL, Karuna ST, Hyrien O, Skalland T, Mayer KH, et al. (2024) Safety and pharmacokinetics of VRC07-523LS administered via different routes and doses (HVTN 127/HPTN 087): A Phase I randomized clinical trial. PLoS Med 21(6): e1004329.
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Jun 11, 2024 | 
nature.com | Christopher Mason |James Green |Jordan Baechle |Mathias Basner |Susan Bailey |Joseph Borg | +34 more
AbstractThe recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a ‘second space age’.
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May 22, 2024 | 
nature.com | Boris Julg |Kathryn E. Stephenson |Stephen Walsh |C. Sabrina Tan |Michal Sarnecki |Diane G Kanjilal | +5 more
AbstractMosaic HIV-1 vaccines have been shown to elicit robust humoral and cellular immune responses in people living with HIV-1 (PLWH), that had started antiretroviral therapy (ART) during acute infection. We evaluated the safety and immunogenicity of 2 mosaic vaccine regimens in virologically suppressed individuals that had initiated ART during the chronic phase of infection, exemplifying the majority of PLWH.
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May 9, 2024 | 
onlinelibrary.wiley.com | Francisco Javier Pérez-Areales |Shalini Rao |Stephen Walsh |Poppy L. Martin
Introduction Arginine methylation is a post translational modification (PTM) that regulates many cellular processes including signal transduction, mRNA splicing, transcriptional control, DNA repair and protein translocation.1 The protein arginine methyltransferases (PRMTs) are a family of proteins responsible for the transfer of a methyl group from S-adenosyl methionine (SAM) to the guanidium group of arginine residues in protein substrates.
