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3 weeks ago | 
downthetubes.net | John Freeman |Stephen Walsh |Keith Page
Peterborough Museum & Art Gallery is the current host of the long-running touring exhibition, “The Wonderful World of the Ladybird Book Artists”, a collection loaned by Helen Day, curator of the indispensable Ladybird Fly Away Home vintage book site.
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Jul 15, 2024 | 
biorxiv.org | Keith Siew |Stephen Walsh |Rebecca H. Finch |Geraldine Vitry
AbstractTo explore new worlds we must ensure humans can survive and thrive in the space environment. Incidence of kidney stones in astronauts is a major risk factor associated with long term missions, caused by increased blood calcium levels due to bone demineralisation triggered by microgravity and space radiation. Transcriptomic changes have been observed in other tissues during spaceflight, including the kidney.
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Jun 24, 2024 | 
journals.plos.org | Stephen Walsh |Cynthia L. Gay |Shelly Karuna |Ollivier Hyrien
Loading metrics Open Access Peer-reviewedResearch Article Citation: Walsh SR, Gay CL, Karuna ST, Hyrien O, Skalland T, Mayer KH, et al. (2024) Safety and pharmacokinetics of VRC07-523LS administered via different routes and doses (HVTN 127/HPTN 087): A Phase I randomized clinical trial. PLoS Med 21(6): e1004329.
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Jun 11, 2024 | 
nature.com | Christopher Mason |James Green |Jordan Baechle |Mathias Basner |Susan Bailey |Joseph Borg | +34 more
AbstractThe recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a ‘second space age’.
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May 22, 2024 | 
nature.com | Boris Julg |Kathryn E. Stephenson |Stephen Walsh |C. Sabrina Tan |Michal Sarnecki |Diane G Kanjilal | +5 more
AbstractMosaic HIV-1 vaccines have been shown to elicit robust humoral and cellular immune responses in people living with HIV-1 (PLWH), that had started antiretroviral therapy (ART) during acute infection. We evaluated the safety and immunogenicity of 2 mosaic vaccine regimens in virologically suppressed individuals that had initiated ART during the chronic phase of infection, exemplifying the majority of PLWH.
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May 9, 2024 | 
onlinelibrary.wiley.com | Francisco Javier Pérez-Areales |Shalini Rao |Stephen Walsh |Poppy L. Martin
Introduction Arginine methylation is a post translational modification (PTM) that regulates many cellular processes including signal transduction, mRNA splicing, transcriptional control, DNA repair and protein translocation.1 The protein arginine methyltransferases (PRMTs) are a family of proteins responsible for the transfer of a methyl group from S-adenosyl methionine (SAM) to the guanidium group of arginine residues in protein substrates.
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May 9, 2024 | 
chemistry-europe.onlinelibrary.wiley.com | Francisco Javier Pérez-Areales |Stephen Walsh |Jason Carroll |David R Spring
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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Mar 18, 2024 | 
medrxiv.org | Nathan Erdmann |Wilton B. Williams |Stephen Walsh |Nicole A. Grunenberg
SRW has received institutional funding from the National Institute of Allergy and Infectious Diseases/National Institutes of Health; and institutional grants or contracts from Sanofi Pasteur, Janssen Vaccines/Johnson & Johnson, Moderna Tx, Pfizer, Vir Biotechnology, and Worcester HIV Vaccine; has participated on data safety monitoring or advisory boards for Janssen Vaccines/Johnson & Johnson and BioNTech; and his spouse holds stock/stock options in Regeneron Pharmaceuticals.
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Feb 23, 2024 | 
biorxiv.org | Zhen Sun |Stephen Walsh |Chutong Zhong |Alessandra Grillo
AbstractThis review examines the crucial role of human cellular models in renal physiology research, with a specific focus on the distal convoluted tubule (DCT). It aims to provide a comprehensive summary of the origins, culture practices, and genetic studies associated with commonly employed DCT cell models. To achieve this, a systematic literature review was performed on Europe PMC, employing a Boolean search strategy.
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Feb 15, 2024 | 
elifesciences.org | Robert J. Bastidas |Robert Davidson |Stephen Walsh |Lee Dolat
eLife assessment This important study combines state-of-the art proteomics and genetic manipulation of Chlamydia trachomatis to study the function of a chlamydial effector, Cdu1, with deubiquitination and acetylation activities.
