Robin Dowell

2 weeks ago | genomebiology.biomedcentral.com | Taylor Jones |Rutendo F. Sigauke |Lynn Sanford |Dylan J. Taatjes |Mary Allen |Robin Dowell

The stand-alone TF Profiler application can be found on github (https://github.com/Dowell-Lab/TF_profiler) and Zenodo [76]. TF Profiler takes an annotation file for bidirectional regions from a nascent sequencing experiment and derives a TF activity profile. This includes generating simulated sequences based on the base composition of the regions provided, scanning for PSSM hits within the genome and statistically assessing TF enrichment and depletion.

May 29, 2024 | nature.com | Sana D. Karam |Robin Dowell

AbstractDynamic regulation of gene expression is fundamental for cellular adaptation to exogenous stressors. P-TEFb-mediated pause-release of RNA polymerase II (Pol II) is a conserved regulatory mechanism for synchronous transcriptional induction in response to heat shock, but this pro-survival role has not been examined in the applied context of cancer therapy.