Romain Icick

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Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder - Nature Mental Health

Jan 7, 2025 | nature.com | Romain Icick |Oleksandr Frei |Hang Zhou |Howard J. Edenberg |Joel Gelernter |Olav B. Smeland

AbstractAlcohol use disorder (AUD) is highly heritable and burdensome worldwide. Genome-wide association studies can provide new evidence regarding the etiology of AUD. We report a multi-ancestry genome-wide association study focusing on a narrow AUD phenotype, using novel statistical tools in a total sample of 1,041,450 individuals (102,079 cases; European, 75,583; African, 20,689 (mostly African American); Hispanic American, 3,449; East Asian, 2,254; South Asian, 104; descent).
Genome‐wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression

Apr 28, 2023 | onlinelibrary.wiley.com | Alexey Shadrin |Børge Holen |Romain Icick |Tahir T. Filiz

Genetic locus definition We defined independent genetic loci according to the FUMA protocol.40 Briefly, independent significant genetic variants were identified as variants with conjFDR < 0.05 and LD r2 < 0.6 with each other. A subset of these independent significant variants with LD r2 < 0.1 was then selected as lead variants.

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