Romain Icick

Jan 7, 2025 | nature.com | Romain Icick |Oleksandr Frei |Hang Zhou |Howard J. Edenberg |Joel Gelernter |Olav B. Smeland

AbstractAlcohol use disorder (AUD) is highly heritable and burdensome worldwide. Genome-wide association studies can provide new evidence regarding the etiology of AUD. We report a multi-ancestry genome-wide association study focusing on a narrow AUD phenotype, using novel statistical tools in a total sample of 1,041,450 individuals (102,079 cases; European, 75,583; African, 20,689 (mostly African American); Hispanic American, 3,449; East Asian, 2,254; South Asian, 104; descent).