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1 month ago | 
nature.com | Pravesh Parekh |Sara Stinson |Maria Koromina |Jaroslav Rokicki |Ida E Sønderby |Nadine Staples Parker | +11 more
AbstractMetabolites in plasma form biosignatures of a range of common complex human diseases. Discovering variants with pleiotropic effects across metabolites can reveal underlying biological mechanisms. We therefore performed uni- and multivariate genome-wide association studies (GWAS) on 249 circulating metabolic markers across 328,006 UK Biobank and Estonian Biobank participants.
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Jan 17, 2025 | 
nature.com | Elise Koch |Nadine Staples Parker |Siobhan K. Lock |Oleksandr Frei |Anders M. Dale |Srdjan Djurovic | +1 more
AbstractWhile clozapine is the most effective antipsychotic drug, its use is limited due to hematological adverse effects involving the reduction of granulocyte counts with potential life-threatening agranulocytosis. It is not yet possible to predict or prevent the risk of agranulocytosis, and the mechanisms are unknown but likely related to clozapine metabolism. Genome-wide association studies (GWASs) of clozapine metabolism and clozapine-induced agranulocytosis have identified few genetic loci.
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Jan 15, 2025 | 
medrxiv.org | Andrew Grotzinger |Josefin Werme |Wouter J. Peyrot |Oleksandr Frei
J.W.S. is a member of the Scientific Advisory Board of Sensorium Therapeutics (with equity) and has received an honorarium for an internal seminar Tempus Labs. K.P.J. is a consultant for Allia Health. A.D.B. has received a speaker fee from Lundbeck.
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Jan 7, 2025 | 
nature.com | Romain Icick |Oleksandr Frei |Hang Zhou |Howard J. Edenberg |Joel Gelernter |Olav B. Smeland
AbstractAlcohol use disorder (AUD) is highly heritable and burdensome worldwide. Genome-wide association studies can provide new evidence regarding the etiology of AUD. We report a multi-ancestry genome-wide association study focusing on a narrow AUD phenotype, using novel statistical tools in a total sample of 1,041,450 individuals (102,079 cases; European, 75,583; African, 20,689 (mostly African American); Hispanic American, 3,449; East Asian, 2,254; South Asian, 104; descent).
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Jan 6, 2025 | 
medrxiv.org | Evgeniia Frei |Oleksandr Frei |Robert Loughnan |Tahir Tekin Filiz
Professor Ole A. Andreassen has received speaker fees from Lundbeck, Janssen, Otsuka, and Sunovion, and is a consultant to Cortechs.ai, and Precision Health AS. Dr. Oleksandr Frei is a consultant to Precision Health AS. No potential conflict of interest was reported by other authors.
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Jun 16, 2024 | 
nature.com | Jacob Bergstedt |Ziyan Ma |Shuyang Yao |Nadine Staples Parker |Oleksandr Frei |Joeri J. Meijsen | +12 more
AbstractMajor depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the involvement of the thalamus.
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Jun 3, 2024 | 
nature.com | Oleksandr Frei |Guy Hindley |Espen Hagen |Nadine Staples Parker |Olav B. Smeland |Christiaan de Leeuw | +2 more
AbstractWhile genome-wide association studies are increasingly successful in discovering genomic loci associated with complex human traits and disorders, the biological interpretation of these findings remains challenging.
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Jan 29, 2024 | 
onlinelibrary.wiley.com | Pravesh Parekh |Chun Chieh Fan |Oleksandr Frei |Clare Palmer
1 INTRODUCTION As neuroimaging studies have moved to large sample sizes, the size of datasets and the complexity of relationships among observations within these datasets pose several challenges to neuroimaging analysis. For example, in the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®) (https://abcdstudy.org), the inclusion of twins and siblings, in addition to a longitudinal design, make it necessary to simultaneously consider multiple correlations among observations.
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Sep 27, 2023 | 
nature.com | Nadine Staples Parker |Pravesh Parekh |Ivan Maximov |Olav B. Smeland |Srdjan Djurovic |Anders M. Dale | +2 more
AbstractImproved understanding of the shared genetic architecture between psychiatric disorders and brain white matter may provide mechanistic insights for observed phenotypic associations. Our objective is to characterize the shared genetic architecture of bipolar disorder (BD), major depression (MD), and schizophrenia (SZ) with white matter fractional anisotropy (FA) and identify shared genetic loci to uncover biological underpinnings.
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Sep 14, 2023 | 
nature.com | Shahram Bahrami |Oleksandr Frei |Guy Hindley |Anders M. Dale |Srdjan Djurovic |Sigrun Hope
AbstractAutism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational attainment (EDU)), and risk loci jointly associated with ASD and the cognitive traits. We analyzed data from genome-wide association studies (GWAS) of INT (n = 269,867), EDU (n = 766,345) and ASD (cases n = 18,381, controls n = 27,969).
