Russell Jenkins

5 days ago | jitc.bmj.com | Ryan Sullivan |Anthony R. Cillo |Robert Ferris |Russell Jenkins

Introduction The Society for Immunotherapy of Cancer (SITC) gathered a diverse group of experts across the cancer immunotherapy landscape to identify challenges and opportunities in cancer immunotherapy, which were outlined in the prefatory manuscript.1 This manuscript serves to further address three of the outlined topics: mechanisms of anti-tumor activity and toxicity, mechanisms of drug resistance, and highlight additional opportunities to leverage our understanding to optimize...

Aug 26, 2024 | nature.com | Meghan J. Mooradian |Florian J. Fintelmann |Thomas LaSalle |Alexander Graur |Sophia Z. Shalhout |Howard L. Kaufman | +4 more

AbstractImage-guided percutaneous cryoablation is an established minimally invasive oncologic treatment. We hypothesized that cryoablation may modify the immune microenvironment through direct modulation of the tumor, thereby generating an anti-tumor response in tumors refractory to immune checkpoint inhibition (ICI).