Ryan M. Wyllie

Oct 1, 2024 | biorxiv.org | Paul Jensen |Ryan M. Wyllie

AbstractMicrobes use quorum sensing systems to respond to ecological and environmental changes. In the oral microbiome, the pathogenic bacterium Streptococcus mutans uses quorum sensing to control the production of bacteriocins. These antimicrobial peptides kill off ecological competetors and allow S. mutans to dominate the microenviornment of dental plaques and form dental caries. One class of bacteriocins produced by S.

Oct 1, 2024 | biorxiv.org | John Richardson |Emily Guo |Ryan M. Wyllie |Paul Jensen

AbstractStreptococcus pneumoniae is an important human pathogen that normally resides in the human nasopharynx. Competence mediated bacteriocin expression by S pneumoniae plays a major role in both the establishment and persistence of colonization on this polymicrobial surface. Over 20 distinct bacteriocin loci have been identified in pneumococcal genomes, but only a small number have been characterized phenotypically. In this work, we demonstrate that 3/4th of S.