Salik Nazki

Oct 10, 2023 | nature.com | Daniel H. Goldhill |Carol M. Sheppard |Ksenia Sukhova |Jonathan Brown |Ciara Y. Campbell |Salik Nazki | +6 more

AbstractChickens genetically resistant to avian influenza could prevent future outbreaks. In chickens, influenza A virus (IAV) relies on host protein ANP32A. Here we use CRISPR/Cas9 to generate homozygous gene edited (GE) chickens containing two ANP32A amino acid substitutions that prevent viral polymerase interaction. After IAV challenge, 9/10 edited chickens remain uninfected. Challenge with a higher dose, however, led to breakthrough infections.

Aug 17, 2023 | microbiologyresearch.org | Sarah Francois |Salik Nazki |Stephen Vickers |Guillaume Fournié

Article metrics loading... /content/journal/jgv/10.1099/jgv.0.001883Download as PowerPoint /deliver/fulltext/jgv/104/8/jgv001883.html?itemId=/content/journal/jgv/10.1099/jgv.0.001883&mimeType=html&fmt=ahah References Woolhouse M, Scott F, Hudson Z, Howey R, Chase-Topping M. Human viruses: discovery and emergence. Phil Trans R Soc B 2012; 367:2864–2871 [View Article][Google Scholar] Jones KE, Patel NG, Levy MA, Storeygard A, Balk D et al. Global trends in emerging infectious diseases.

Jun 8, 2023 | biorxiv.org | Sarah Francois |Salik Nazki |Stephen Vickers |Guillaume Fournié

New Results doi: https://doi.org/10.1101/2023.06.08.544213 AbstractViruses emerging from wildlife can cause outbreaks in humans and domesticated animals. Predicting the emergence of future pathogens and mitigating their impacts requires an understanding of what shapes virus diversity and dynamics in wildlife reservoirs.