Samantha Perez-Miller

Jul 31, 2024 | biorxiv.org | David Scott |Lipsa Jena |Samantha Perez-Miller |Vlad Kumirov

AbstractTAR DNA-binding Protein 43 (TDP-43) plays a crucial role in the pathophysiology and progression of Amyotrophic Lateral Sclerosis (ALS), affecting both familial and sporadic cases. TDP-43 is an intrinsically disordered multidomain protein that consists of an N-terminal domain (NTD1-102), two tandem RNA recognition motifs (RRM1102-177 and RRM2191-260), and an intrinsically disordered glycine-rich C-terminal261-414 domain.

Dec 27, 2023 | newatlas.com | Samantha Perez-Miller |Rajesh Khanna |Paul McClure

Throughout 2023, researchers have looked at pain, especially chronic pain, and its molecular mechanisms, in an effort to find new, targeted ways to effectively resolve the complex condition. We present this year’s top discoveries in pain research. The world’s most painful sting provides a deeper understandingResearchers have learned a lot from nature, including insects.

Jul 27, 2023 | newatlas.com | Bronwyn Thompson |Samantha Perez-Miller |Rajesh Khanna

The National Institute of Health estimates that 100 million Americans, or around a third of the US population, live with a chronic pain condition. While the economic burden, more than US$500 billion annually, is well documented, increasingly studied is its wide-ranging impact on mental health and the growth in opioid addiction.