Vlad Kumirov

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Synthesis of Polycyclic Olefinic Monomers from Norbornadiene for Inverse Vulcanization: Structural and Mechanistic Consequences

Aug 14, 2024 | dx.doi.org | Christopher Marshall |Jake Molineux |Kyung-Seok Kang |Vlad Kumirov
Synthesis of Polycyclic Olefinic Monomers from Norbornadiene for Inverse Vulcanization: Structural and Mechanistic Consequences

Aug 14, 2024 | dx.doi.org | Christopher Marshall |Jake Molineux |Kyung-Seok Kang |Vlad Kumirov
Identifying interactions between TDP-43 N-terminal and RNA binding domains

Jul 31, 2024 | biorxiv.org | David Scott |Lipsa Jena |Samantha Perez-Miller |Vlad Kumirov

AbstractTAR DNA-binding Protein 43 (TDP-43) plays a crucial role in the pathophysiology and progression of Amyotrophic Lateral Sclerosis (ALS), affecting both familial and sporadic cases. TDP-43 is an intrinsically disordered multidomain protein that consists of an N-terminal domain (NTD1-102), two tandem RNA recognition motifs (RRM1102-177 and RRM2191-260), and an intrinsically disordered glycine-rich C-terminal261-414 domain.

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