Samuel I. Mann

Oct 1, 2024 | biorxiv.org | Samuel I. Mann |Zhi Yi Lin |Sophia Tan |Jiaqi Zhu

AbstractDe novo protein design provides a framework to test our understanding of protein function. Ligand binding, while simple in concept, is an ongoing challenge requiring precise placement of polar groups within a protein core. Ad-dressing this challenge enables binding of abiological cofactors with interesting chemical properties. Here, we report the design of a helical bundle to bind naphthalenediimides (NDIs), powerful photooxidants with tunable photo-physical properties.