Zhi Yi Lin

Oct 1, 2024 | biorxiv.org | Samuel I. Mann |Zhi Yi Lin |Sophia Tan |Jiaqi Zhu

AbstractDe novo protein design provides a framework to test our understanding of protein function. Ligand binding, while simple in concept, is an ongoing challenge requiring precise placement of polar groups within a protein core. Ad-dressing this challenge enables binding of abiological cofactors with interesting chemical properties. Here, we report the design of a helical bundle to bind naphthalenediimides (NDIs), powerful photooxidants with tunable photo-physical properties.

Jul 18, 2024 | science.org | Jacob H Wilde |Anurag Verma |Zhi Yi Lin |Peter Yoon

AbstractThe RNA-guided ribonuclease CRISPR-Cas13 enables adaptive immunity in bacteria and programmable RNA manipulation in heterologous systems. Cas13s share limited sequence similarity, hindering discovery of related or ancestral systems. To address this, we developed an automated structural-search pipeline to identify an ancestral clade of Cas13 (Cas13an), and further trace Cas13 origins to defense-associated ribonucleases.

Jul 18, 2024 | science.org | Jacob H Wilde |Anurag Verma |Zhi Yi Lin |Ke Huang

AbstractEdge states of a topological insulator can be used to explore fundamental science emerging at the interface of low dimensionality and topology. Achieving a robust conductance quantization, however, has proven challenging for helical edge states. Here we show wide resistance plateaus in kink states – a manifestation of the quantum valley Hall effect in Bernal bilayer graphene – quantized to the predicted value at zero magnetic field.

Jul 18, 2024 | science.org | Jacob H Wilde |Anurag Verma |Zhi Yi Lin |Anna L. Hargreaves

PerspectiveEcologyForaging niches become more specialized toward bird range limitsAnna L. Hargreaves [email protected] and Jake M. Alexander [email protected] Info & AffiliationsScience18 Jul 2024Vol 385, Issue 6706pp. 260-261AbstractChildren are often taught about the natural world through facts about species, such as what a toucan eats. Yet species are not homogeneous, and different populations within a species vary in how they use their environment.

Jul 18, 2024 | science.org | Jacob H Wilde |Anurag Verma |Zhi Yi Lin |Agustín Fuentes

Any scientist knows that to be a good scientist, they must conduct thoughtful research; generate high-quality, verifiable results and analyses; and get them into circulation in the scientific community. However, what often goes underappreciated is that this good science will likely remain ignored by most of the world if one doesn’t find a way to get it out beyond the scientific community. Unfortunately, when it comes to making our science accessible, we scientists all too often fall short.