Sanford Research

Aug 26, 2024 | thelancet.com | Sanford Research

References1. Insel, RA ∙ Dunne, JL ∙ Atkinson, MA ∙ et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes AssociationDiabetes Care. 2015; 38:1964-19742. Ziegler, AG ∙ Rewers, M ∙ Simell, O ∙ et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in childrenJAMA. 2013; 309:2473-24793. Hummel, S ∙ Carl, J ∙ Friedl, N ∙ et al.

May 29, 2024 | thelancet.com | David Pearce |Sanford Research |Gareth Baynam

The Editorial on the landscape for rare diseases in 20241The landscape for rare diseases in 2024. offered insight into the challenges faced by people living with a rare disease, highlighting the need for collective action to address their unmet needs.

Nov 20, 2023 | aacrjournals.org | Sanford Research

Purpose: The safety, pharmacokinetics and efficacy of elraglusib, a GSK-3b small molecule inhibitor, as monotherapy or combined with chemotherapy, in patients with relapsed or refractory solid tumors or hematologic malignancies was studied.

Sep 22, 2023 | cell.com | Sanford Research |Pablo Gainza |Bruno E. Correia

Highlights•Systematic analysis of GPCR enzymatic activity unveils G protein selectivity across 124 GPCRs•Functional rank-order-based classification for GPCRs is introduced•Machine learning accurately predicts GPRC-Gα selectivity•Natural genetic variation in GPCRs influences their G protein preferencesSummaryG protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13.

Jun 22, 2023 | frontiersin.org | Sanford Research |Bangladesh Agricultural |Mostafa Bakhti |Ezgi Hacisuleyman

IntroductionType 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction of insulin-producing β cells in the pancreas. Its progression involves complex interactions between genetic, environmental, and immunological factors (1). Genetic factors play a significant role in the progression of T1D, influencing both susceptibility and disease severity. A study conducted by Redondo et al.