Sarah E. Conduit

Aug 20, 2024 | nature.com | Sarah E. Conduit |Laura Bozal-Basterra |Mathias Cobbaut |Sandra D Castillo |Arkaitz Carracedo |Mariona Graupera | +5 more

AbstractPrimary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the process by which cells lose their cilium, is poorly understood but frequently observed in disease and upon cell transformation. Here, we uncover a role for the PI3Kα signalling enzyme in cilia disassembly.