Mathias Cobbaut

Sep 26, 2024 | biorxiv.org | Mathias Cobbaut |André Carvalho |Marina Ivanova |Christopher P. Earl

AbstractThe mutually antagonistic kinase-substrate relationship between the apical aPKC-Par6 heterodimer and the basolateral substrate Lgl is key to the establishment and maintenance of cell polarity across metazoa. Although aPKC-Par6 can phosphorylate Lgl at three serine sites to exclude it from the apical domain, paradoxically, aPKC-Par6 and Lgl can also form a stable kinase-substrate complex whose function remains unclear and with conflicting roles proposed for Par6.

Aug 20, 2024 | nature.com | Sarah E. Conduit |Laura Bozal-Basterra |Mathias Cobbaut |Sandra D Castillo |Arkaitz Carracedo |Mariona Graupera | +5 more

AbstractPrimary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the process by which cells lose their cilium, is poorly understood but frequently observed in disease and upon cell transformation. Here, we uncover a role for the PI3Kα signalling enzyme in cilia disassembly.