Sarasa Isobe

Nov 20, 2023 | nature.com | Sarasa Isobe |Rebecca Harper |Jakob Körbelin |Jesse M. Engreitz |Michael Snyder |Shoichiro Otsuki | +2 more

AbstractPulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial (PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 is the most common genetic cause of PAH. We report that human PAEC with reduced BMPR2 have persistent DNA damage in room air after hypoxia (reoxygenation), as do mice with EC-specific deletion of Bmpr2 (EC-Bmpr2-/-) and persistent pulmonary hypertension.