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3 weeks ago | 
nature.com | Chiara Herzog |Kejun Ying |Raghav Sehgal |Waylon J. Hastings |Alexander Tyshkovskiy |Sara Hägg | +19 more
On 1–2 November 2024, the annual Biomarkers of Aging conference welcomed academic and industry scientists, and partners from governmental and nongovernmental organizations, to Harvard Medical School in Boston, USA, to discuss new insights into measuring and monitoring human aging, with the aim of clinical translation. In this Meeting Report, we summarize the conference and offer potential future directions for the Biomarkers of Aging Consortium and the longevity science community at large.
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2 months ago | 
nature.com | Michael Snyder |Hayan Lee |Annika K Weimer |Aaron M Horning |Edward D. Esplin |Kristina Ayers Paul | +4 more
Correction to: Nature Cancer https://doi.org/10.1038/s43018-024-00823-z, published online 30 October 2024. In the version of the article initially published, a technique described as “intact Micro-C” should have been called “MNase-digested Intact Hi-C” and has now been corrected throughout the article.
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Sep 15, 2024 | 
nature.com | Jesse R. Poganik |Daniel Belsky |Joe LaCroix |Alan Cohen |Steven R. Cummings |Luigi Ferrucci | +15 more
AbstractBiomarkers of aging (BOA) are quantitative parameters that predict biological age and ideally its changes in response to interventions. In recent years, many promising molecular and omic BOA have emerged with an enormous potential for translational geroscience and improving healthspan. However, clinical translation remains limited, in part due to the gap between preclinical research and the application of BOA in clinical research and other translational settings.
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Aug 23, 2024 | 
nature.com | Christine Yeh |Olivia Laveroni |Subin Kim |Aihui Wang |Brooke Liang |Raeline Valbuena | +4 more
AbstractThe drivers of immune evasion are not entirely clear, limiting the success of cancer immunotherapies. Here we applied single-cell spatial and perturbational transcriptomics to delineate immune evasion in high-grade serous tubo-ovarian cancer. To this end, we first mapped the spatial organization of high-grade serous tubo-ovarian cancer by profiling more than 2.5 million cells in situ in 130 tumors from 94 patients.
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May 19, 2024 | 
conservativefiringline.com | Michael Snyder
Once thousands of nanobots are zipping around inside your body, will you still be in control of your mind, will and emotions or will the nanobots be running the show? According to Google, a nanobot is “a hypothetical, very small, self-propelled machine, especially one that has some degree of autonomy and can reproduce”.
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May 17, 2024 | 
nature.com | Brian D. Piening |Maedeh Mohebnasab |Bo Xia |Jeffrey S. Stern |Weimin Zhang |Jacqueline I. Kim | +20 more
AbstractIn a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand the detailed molecular landscape following xenotransplantation, we carried out bulk and single-cell transcriptomics, lipidomics, proteomics and metabolomics on blood samples obtained from the transplanted decedents every 6 h, as well as histological and transcriptomic tissue profiling.
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Mar 13, 2024 | 
mchnews.com | Michael Snyder
Greetings Stockport! This is a big local news day so I must be brief, but I have to mention a concern about kids playing on the wooden steps along the river. That area is off limits, so make sure your kids and grandkids know that. And on a lighter note, it’s time to vote! Election day is March 19, at […]
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Feb 14, 2024 | 
nature.com | Chiara Herzog |Jesse R. Poganik |Kejun Ying |Daniel Belsky |Albert T. Higgins-Chen |Alan Cohen | +12 more
AbstractThe search for biomarkers that quantify biological aging (particularly ‘omic’-based biomarkers) has intensified in recent years. Such biomarkers could predict aging-related outcomes and could serve as surrogate endpoints for the evaluation of interventions promoting healthy aging and longevity. However, no consensus exists on how biomarkers of aging should be validated before their translation to the clinic.
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Nov 29, 2023 | 
mchnews.com | Michael Snyder
Greetings Stockport! I can hardly believe Thanksgiving is behind us and December is just around the corner. There is so much going on that I can’t add much but I will remind you this it is gun season this week. So, watch out for hunters and panicked animals as you drive around the county. And one other thing… it’s the […]
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Nov 22, 2023 | 
mchnews.com | Michael Snyder
Greetings Stockport! Thanksgiving comes a little earlier than usual this year. In fact, it’s this Thursday. That also means that the ceremonial tree lighting will be early too. Stockport C of C will host, and there will be some caroling at 6 p.m. Monday, Nov. 27, at the pavilion beside the community center, and light refreshments at the HECK afterward. […]
