Satish K. Nandakumar

Sep 8, 2023 | nature.com | Derek Brown |Yajie Zhao |Satish K. Nandakumar |Erik L. Bao |Stephen J. Chanock |Vijay Sankaran

AbstractClonal hematopoiesis (CH)—age-related expansion of mutated hematopoietic clones—can differ in frequency and cellular fitness by CH type (e.g., mutations in driver genes (CHIP), gains/losses and copy-neutral loss of chromosomal segments (mCAs), and loss of sex chromosomes). Co-occurring CH raises questions as to their origin, selection, and impact.