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Aug 20, 2024 | 
nature.com | Stephen J. Chanock
Precision oncology has just received a boost: a report on the prevalence of mutations in cancer driver genes based on whole genome sequencing of 10,000 clinical cases. The challenge ahead lies in how to explore the data to accelerate new discoveries in cancer biology while advancing precision oncology.
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Jun 12, 2024 | 
nature.com | Aoxing Liu |Giulio Genovese |Yajie Zhao |Matti Pirinen |Xiaoxi Liu |Bryan R. Gorman | +15 more
AbstractMosaic loss of the X chromosome (mLOX) is the most common clonal somatic alteration in leukocytes of female individuals1,2, but little is known about its genetic determinants or phenotypic consequences. Here, to address this, we used data from 883,574 female participants across 8 biobanks; 12% of participants exhibited detectable mLOX in approximately 2% of leukocytes. Female participants with mLOX had an increased risk of myeloid and lymphoid leukaemias.
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Apr 28, 2024 | 
nature.com | Karl Smith-Byrne |Marios Dimitriou |Mine Koprulu |Maik Pietzner |Claudia Langenberg |Joshua Atkins | +10 more
AbstractCirculating proteins can reveal key pathways to cancer and identify therapeutic targets for cancer prevention. We investigate 2,074 circulating proteins and risk of nine common cancers (bladder, breast, endometrium, head and neck, lung, ovary, pancreas, kidney, and malignant non-melanoma) using cis protein Mendelian randomisation and colocalization. We conduct additional analyses to identify adverse side-effects of altering risk proteins and map cancer risk proteins to drug targets.
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Apr 26, 2024 | 
nature.com | Stephen J. Chanock
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Mar 7, 2024 | 
nature.com | Todd Gibson |Stephen W. Hartley |Wendy M. Leisenring |Lucie Turcotte |Stephen J. Chanock
AbstractSurvivors of childhood cancer are at increased risk for subsequent cancers attributable to the late effects of radiotherapy and other treatment exposures; thus, further understanding of the impact of genetic predisposition on risk is needed.
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Oct 2, 2023 | 
nature.com | Minta Thomas |Elisabeth Rosenthal |Lori C. Sakoda |Stephanie Schmit |Maria Timofeeva |Ceres Fernández-Rozadilla | +60 more
AbstractPolygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations.
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Oct 2, 2023 | nature.com | Minta Thomas |Elisabeth Rosenthal |Lori C. Sakoda |Stephanie Schmit |Maria Timofeeva |Ceres Fernández-Rozadilla | +60 more
AbstractPolygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations.
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Sep 8, 2023 | 
nature.com | Derek Brown |Yajie Zhao |Satish K. Nandakumar |Erik L. Bao |Stephen J. Chanock |Vijay Sankaran
AbstractClonal hematopoiesis (CH)—age-related expansion of mutated hematopoietic clones—can differ in frequency and cellular fitness by CH type (e.g., mutations in driver genes (CHIP), gains/losses and copy-neutral loss of chromosomal segments (mCAs), and loss of sex chromosomes). Co-occurring CH raises questions as to their origin, selection, and impact.
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Sep 4, 2023 | 
nature.com | Sonja I. Berndt |Nicola J. Camp |Zhaoming Wang |Henrik Hjalgrim |Caroline Besson |Lindsay Morton | +26 more
Correction to: Leukemia https://doi.org/10.1038/s41375-022-01711-0, published online 22 October 2022In this article Arjan Diepstra at affiliation Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands was missing from the author list. The original article has been corrected. About this articleBerndt, S.I., Vijai, J., Benavente, Y. et al.
