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Oct 23, 2024 | 
nature.com | Vijay Sankaran
An emerging treatment option for genetic diseases that affect the blood and immune system is haematopoietic stem cell (HSC) gene therapy. In ‘autologous’ HSC gene therapy, a person’s own haematopoietic stem and progenitor cells (HSPCs) are collected and genetically modified to restore normal gene function, and then transplanted back into that person to re-establish the production of blood and immune cells (haematopoiesis) in the bone marrow.
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Aug 24, 2024 | 
biorxiv.org | Chen Weng |Jonathan S. Weissman |Vijay Sankaran
AbstractThe detection of mitochondrial DNA (mtDNA) mutations in single cells holds considerable potential to define clonal relationships coupled with information on cell state in humans. Previous methods focused on higher heteroplasmy mutations that are limited in number and can be influenced by functional selection, introducing biases for lineage tracing.
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Jun 12, 2024 | 
nature.com | Aoxing Liu |Giulio Genovese |Yajie Zhao |Matti Pirinen |Xiaoxi Liu |Bryan R. Gorman | +15 more
AbstractMosaic loss of the X chromosome (mLOX) is the most common clonal somatic alteration in leukocytes of female individuals1,2, but little is known about its genetic determinants or phenotypic consequences. Here, to address this, we used data from 883,574 female participants across 8 biobanks; 12% of participants exhibited detectable mLOX in approximately 2% of leukocytes. Female participants with mLOX had an increased risk of myeloid and lymphoid leukaemias.
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Feb 29, 2024 | 
nature.com | Enyong Dai |Xin McRae Chen |Xuejun Jiang |Rui Kang |Valerian E. Kagan |Ana J. García-Sáez | +27 more
AbstractFerroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity.
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Nov 4, 2023 | 
ciotalknetwork.com | Vijay Sankaran
As AI gets more complex, making decisions harder to understand, Explainable AI (XAI) becomes crucial. It’s not just about tech anymore; it’s about trust, ethics, and clear communication. So, a big challenge emerges: How are business and IT heads working together to balance a clear AI “story” with a highly accurate model? And with different AI rules in different countries, how are they keeping up and making the right calls in this fast-evolving AI world?
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Sep 14, 2023 | 00904-2&sz=64)
cell.com | Vijay Sankaran |Samantha Joubran
Hematopoiesis requires balance between self-renewal of stem cells and differentiation into mature blood cells, orchestrated by pathways such as thrombopoietin signaling. In this issue of Cell, Tsutsumi et al. report the structure of the thrombopoietin ligand-receptor complex and demonstrate the potential to decouple its roles in self-renewal and hematopoietic differentiation.
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Sep 8, 2023 | 
nature.com | Derek Brown |Yajie Zhao |Satish K. Nandakumar |Erik L. Bao |Stephen J. Chanock |Vijay Sankaran
AbstractClonal hematopoiesis (CH)—age-related expansion of mutated hematopoietic clones—can differ in frequency and cellular fitness by CH type (e.g., mutations in driver genes (CHIP), gains/losses and copy-neutral loss of chromosomal segments (mCAs), and loss of sex chromosomes). Co-occurring CH raises questions as to their origin, selection, and impact.
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Aug 18, 2023 | 
nature.com | Parsa Akbari |Luca Stefanucci |Kousik Kundu |Roman Kreuzhuber |Erik L. Bao |Janine Collins | +12 more
AbstractBlood cells contain functionally important intracellular structures, such as granules, critical to immunity and thrombosis. Quantitative variation in these structures has not been subjected previously to large-scale genetic analysis. We perform genome-wide association studies of 63 flow-cytometry derived cellular phenotypes—including cell-type specific measures of granularity, nucleic acid content and reactivity—in 41,515 participants in the INTERVAL study.
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Mar 31, 2023 | 
firstpost.com | Vijay Sankaran
Mental health is just as important as physical health, yet many individuals fail to prioritise their mental well-being due to a lack of understanding and societal stigma associated with mental health disorders. And when it comes to health insurance, one rarely takes their mental health coverage needs into account in the insurance claim process.
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Feb 15, 2023 | 
nature.com | Caleb A Lareau |Vincent Liu |Samantha D. Praktiknjo |Pauline Kautz |Katalin Sandor |Karin Pelka | +3 more
Authors and AffiliationsDepartment of Pathology, Stanford University, Stanford, CA, USACaleb A. Lareau, Vincent Liu, Katalin Sandor, Yajie Yin, Jacob C. Gutierrez & Ansuman T. SatpathyParker Institute for Cancer Immunotherapy, San Francisco, CA, USACaleb A. Lareau & Ansuman T. SatpathyBroad Institute of MIT and Harvard, Cambridge, MA, USAChristoph Muus & Vijay G.
