Satoshi Koyama

Oct 3, 2024 | nature.com | Satoshi Koyama |Xiaoxi Liu |Yoshinao Koike |Keiko Hikino |Masaru Koido |Wei Li | +13 more

AbstractHuman genetic variants are associated with many traits through largely unknown mechanisms. Here, combining approximately 260,000 Japanese study participants, a Japanese-specific genotype reference panel and statistical fine-mapping, we identified 4,423 significant loci across 63 quantitative traits, among which 601 were new, and 9,406 putatively causal variants.

Aug 13, 2024 | medrxiv.org | Hirotaka Ieki |Kaoru Ito |Sai Zhang |Satoshi Koyama

The authors have declared no competing interest. This study was funded by the Japan Agency for Medical Research and Development (AMED) under grant numbers JP24bm1423005, JP24km0405209, JP24tm0524004, JP24tm0624002, JP24km0405209, JP24ek0210164, JP17km0305002 and JP17km0305001 and JP24tm0624002. K.I. and K.O. are supported by the Research Funding for Longevity Sciences from the NCGG (24 15).

May 11, 2023 | nature.com | Shohei Kojima |Satoshi Koyama |Steven Heaton |Yoichiro Kamatani |Yasuhiro Murakawa |Kazuyoshi Ishigaki | +6 more

AbstractMobile genetic elements (MEs) are heritable mutagens that recursively generate structural variants (SVs). ME variants (MEVs) are difficult to genotype and integrate in statistical genetics, obscuring their impact on genome diversification and traits. We developed a tool that accurately genotypes MEVs using short-read whole-genome sequencing (WGS) and applied it to global human populations.