Keiko Hikino

Oct 3, 2024 | nature.com | Satoshi Koyama |Xiaoxi Liu |Yoshinao Koike |Keiko Hikino |Masaru Koido |Wei Li | +13 more

AbstractHuman genetic variants are associated with many traits through largely unknown mechanisms. Here, combining approximately 260,000 Japanese study participants, a Japanese-specific genotype reference panel and statistical fine-mapping, we identified 4,423 significant loci across 63 quantitative traits, among which 601 were new, and 9,406 putatively causal variants.

Sep 29, 2024 | nature.com | Masatoshi Matsunami |Minako Imamura |Xiaoxi Liu |Keiko Hikino |Koichi Matsuda |Chikashi Terao

AbstractPelvic organ prolapse (POP) affects approximately 40% of elderly women, characterized by the descent of the pelvic organs into the vaginal cavity. Here we present the results of a genome-wide association study (GWAS) for susceptibility to POP comprising 771 cases and 76,625 controls in the Japanese population.

Jun 18, 2024 | jamanetwork.com | Keiko Hikino |Yokohama City |Kaoru Ito |Chikashi Terao

Key PointsQuestion  Can the first large-scale genome-wide association studies of vasospastic angina (VSA) identify risk for VSA? Findings  A genome-wide association study including 5720 cases and 153 864 controls was performed using a large sample size and a nationwide, multicohort study.

May 19, 2024 | nature.com | Xiaoxi Liu |Yoshinao Koike |Keiko Hikino |Yukihide Momozawa |Kouichi Ozaki |Hirotaka Watada | +2 more

AbstractSarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3452 Japanese aged 60 years or older from two independent cohorts.

Jan 31, 2024 | nature.com | Yuki Ishikawa |Nao Tanaka |Mitsuteru Akahoshi |Takashi Matsushita |Akira Oka |Motohisa Yamamoto | +15 more

AbstractHere we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region, which shows a penetrating association in the Asian population, while a complete linkage disequilibrium SNP, rs10917688, is found in a cis-regulatory element for IRF8.