Sean Sun

Nov 22, 2024 | cell.com | Qin Ni |Zhuoxu Ge |Yizeng Li |Gabriel Shatkin |Jinyu Fu |Anindya Sen | +9 more

Keywordscell volumenucleus volumemechanosensationNHE1cytoskeletonPI3KERK/MAPKepigenomeRNA-seqmath modelResearch topic(s)CP: Cell biologyIntroductionCells actively control their size during the cell cycle, and failure of cell size control is an indicator of disease.1,2,3,4,5 Cell size or volume influences all intracellular biochemical reactions by affecting concentrations of cytoplasmic components.

May 13, 2024 | link.aps.org | Yizeng Li |Sean Sun |Johns Hopkins

Anisotropic environmental signals or polarized membrane ion/solute carriers can generate spatially varying intracellular gradients, leading to polarized cell dynamics. For example, the directional migration of neutrophils, galvanotaxis of glioblastoma, and water flux in kidney cells all result from the polarized distribution of membrane ion carriers and other intracellular components.

Jul 27, 2023 | biorxiv.org | Yizeng Li |Sean Sun |Johns Hopkins

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Jul 19, 2023 | cell.com | Yufei Wu |Johns Hopkins |Sean Sun

AbstractTissue cells in epithelial or endothelial monolayers are connected through cell-cell junctions, which are stabilized by transmembrane E-cadherin bonds and intracellular actin filaments. These bonds and junctions play a crucial role in maintaining the barrier function of epithelia and endothelia and are believed to transmit forces between cells. Additionally, E-cadherin bonds can impact the shape of cell-cell junctions.

Mar 26, 2023 | thespec.com | Sean Sun |Sean Highkin

PORTLAND, Ore. (AP) — Shai Gilgeous-Alexander scored 31 points and the Oklahoma City Thunder defeated the depleted Portland Trail Blazers 118-112 on Sunday. Jalen Williams had 23 points and Isaiah Joe added 20 off the bench for Oklahoma City. It was a crucial win for the Thunder in the Western Conference play-in race. They improved to 37-38 and moved into a tie for ninth place with the Los Angeles Lakers.