Sean Whalen

Jan 14, 2025 | biorxiv.org | Jennifer M Umhoefer |Maya M. Arce |Sean Whalen |Rama Dajani

AbstractFOXP3 is a lineage–defining transcription factor (TF) for immune–suppressive regulatory T cells (Tregs). While mice exclusively express FOXP3 in Tregs, humans also transiently express FOXP3 in stimulated conventional CD4+ T cells (Tconvs). Mechanisms governing these distinct expression patterns remain unknown. Here, we performed CRISPR screens tiling the FOXP3 locus and targeting TFs in human Tregs and Tconvs to discover cis–regulatory elements (CREs) and trans–regulators of FOXP3.

Dec 6, 2024 | doomrocket.substack.com | Sean Whalen |Jim Wald |Jarrod Jones

One of the hardest things to do as a critic — especially one who more often writes professionally about TV — is to keep up with every cool-lookin' movie that comes out in a given year. By the time Thanksgiving rolls around, a cold feeling hits my stomach: Best Of lists are forthcoming! Do I know where I stand? Have I seen enough films this year to have an opinion on the best among them? Every year, like clockwork, this happens to me. Luckily, DoomRocket exists.

May 23, 2024 | science.org | W. Brad Ruzicka |Chengyu Deng |Cindy Wen |Sean Whalen

Research ArticlePSYCHENCODE2Chengyu Deng, Sean Whalen, [...] , Marilyn Steyert, Ryan Ziffra, [...] , Pawel F. Przytycki, Fumitaka Inoue, Daniela A. Pereira, Davide Capauto, Scott Norton, [...] , Flora M. Vaccarino, PsychENCODE Consortium, Alex A. Pollen, Tomasz J. Nowakowski, Nadav Ahituv [email protected], and Katherine S.

May 15, 2024 | onlinelibrary.wiley.com | Sean Whalen |Gregory S Young |Emily Sellards |Bradley Gobin

Conflict of interests The authors declare that they have no conflicts of interest relating to the publication of this research. References 1, , , , Russ J. Appl. Chem. 2007, 80, 1295–1299. 2, , , , Russ J. Appl. Chem. 2008, 81, 61–66. 3, , , , , , Int. J. Energetic Mater. Chem. Propul. 2021, 20, 27–44. 4W. N. Sawka, A. Katzakian, C. Grix, Paper SSC05-XI-3, 19th Annual AIAA/USU Small Satellite Conference, 2005. 5W. N. Sawka, M.

Feb 19, 2024 | imdb.com | Jim Wald |Sean Whalen

A depressed has-been child actor and owner of a dingy laundromat, becomes powerfully vengeful when his collection of lone socks transforms into a protective, cute, murderous monster named Cr...