Sergi Simó

Jul 28, 2023 | nature.com | Maria Ximena Casas |María Casas |Sergi Simó |James S. Trimmer |Rose E. Dixon

AbstractLysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is then transferred to the ER for distribution to other cell membranes. Mutations in NPC1 result in cholesterol buildup within lysosomes, leading to Niemann-Pick Type C (NPC) disease, a progressive and fatal neurodegenerative disorder.

May 25, 2023 | frontiersin.org | Sergi Simó |Yong Kim |Hailin Zhang |Xin Zhang

Introduction Joint injuries usually result in persistent joint pain and locomotion impairments (Alghadir et al., 2020). Ankle sprain is one of the most common types of joint injuries that impose heavy financial burdens on the healthcare system (Ivins, 2006; Bielska et al., 2019).