Seth Blackshaw

Jan 19, 2025 | biorxiv.org | Ying Xin |Yang Jin |Cheng Qian |Seth Blackshaw

AbstractNon-peptide ligands (NPLs), including lipids, amino acids, carbohydrates, and non-peptide neurotransmitters and hormones, play a critical role in ligand-receptor-mediated cell-cell communication, driving diverse physiological and pathological processes. To facilitate the study of NPL-dependent intercellular interactions, we introduce MetaLigand, an R-based and web-accessible tool designed to infer NPL production and predict NPL-receptor interactions using transcriptomic data.

Oct 2, 2024 | nature.com | Ingie Hong |Thomas Hainmueller |Dong Won Kim |Richard Johnson |Nathachit Limjunyawong |David Cheon | +7 more

AbstractThe brain helps us survive by forming internal representations of the external world1,2. Excitatory cortical neurons are often precisely tuned to specific external stimuli3,4. However, inhibitory neurons, such as parvalbumin-positive (PV) interneurons, are generally less selective5. PV interneurons differ from excitatory neurons in their neurotransmitter receptor subtypes, including AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors (AMPARs)6,7.

Jul 11, 2024 | onlinelibrary.wiley.com | Seth Blackshaw |Jiang Qian |David Hyde

CONFLICT OF INTEREST STATEMENT Seth Blackshaw receives research support from Genentech, and is a co-founder and shareholder of CDI Labs, LLC. REFERENCES 1, , , , & (2023). Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification. Trends in Genetics: TIG, 39(10), 736–757. 2, & (2012). Cell fate determination in the vertebrate retina. Trends in Neurosciences, 35(9), 565–573. 3, , , , , , , , , , , , , & (2019).