Cheng Qian

Jan 19, 2025 | biorxiv.org | Ying Xin |Yang Jin |Cheng Qian |Seth Blackshaw

AbstractNon-peptide ligands (NPLs), including lipids, amino acids, carbohydrates, and non-peptide neurotransmitters and hormones, play a critical role in ligand-receptor-mediated cell-cell communication, driving diverse physiological and pathological processes. To facilitate the study of NPL-dependent intercellular interactions, we introduce MetaLigand, an R-based and web-accessible tool designed to infer NPL production and predict NPL-receptor interactions using transcriptomic data.

Nov 8, 2024 | mdpi.com | Qiang Zhang |Cheng Qian |Lulu Li |Wei Li

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Aug 23, 2024 | nature.com | Cheng Qian |Tong Wang |Sihan Yu

Wooden buildings represent a unique aspect of China’s architectural heritage. However, over time, these buildings have suffered varying degrees of structural damage, particularly those located in China’s mountainous regions. Frequent natural disasters and inconvenient transportation further exacerbate the vulnerability of these structures. This study focuses on the typical wooden stilt houses found in the Wuling Mountain area of southwest Hubei. The different forms of columns and beams, as well as the overall structural symmetry of the stilt houses, were classified into five common structural types. Precise digital models were established via real photos and collected dimensional data, and these five models were evaluated for static, buckling, utilization, and ultimate limit states. The results indicate that: (1) overall symmetrical structures perform better than asymmetrical ones; (2) structures where all columns are grounded and act as support columns exhibit the best overall mechanical performance; and (3) transverse-tie beams(chuanfang) primarily serve a connecting role rather than a load-bearing role, thus an excess of transverse-tie beams(chuanfang) can reduce the stability of the building structure. Based on the analysis results, targeted protective measures and recommendations were proposed and verified through structural evaluations. These initiatives provide new methods and insights for the protection of architectural heritage.

Jul 5, 2024 | onlinelibrary.wiley.com | Cheng Qian |Daniel Hedman |Pai Li |sung kim

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202404274-sup-0001-SuppMat.pdf2.4 MB Supporting Information References 1, , , Phys. Rev. Lett. 1985, 54, 1725. 2, , , , J. Chem. Phys. 1994, 100, 1202. 3, , Chem. Soc. Rev. 2008, 37, 2224. 4, , , , Nat. Catal. 2020, 3, 30. 5, , , , , , , , , , , , , , , , , Nat. Chem. 2022, 14, 935. 6, , Electrochim. Acta 2002, 47, 3571. 7, , , , , , , J. Phys. Chem.

Mar 2, 2024 | mdpi.com | Wenchao Li |Peng Xu |Cheng Qian |Xing Zhao

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.