Shahram Oveisgharan

2 months ago | digitalcommons.library.tmc.edu | Aron S. Buchman |Lei Yu |Shahram Oveisgharan |Andrea R. Zammit

BACKGROUND: The interrelationship of parkinsonism, Parkinson's disease (PD) and other Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD) pathologies is unclear. OBJECTIVE: We examined the progression of parkinsonian signs in adults with and without parkinsonism, and their underlying brain pathologies. METHODS: Annual parkinsonian signs were based on a modified Unified Parkinson's Disease Rating Scale.

May 14, 2024 | nature.com | Shahram Oveisgharan |Lei Yu |Vladislav A. Petyuk |Ricardo Assunção Vialle |Vilas Menon

AbstractAccumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected. Here, we use data of 1206 elders and test that RNA expression levels of GPER1, a transmembrane protein, modify the association of Aβ with tau tangles. GPER1 RNA expression is related to more tau tangles (p = 0.001).