Aron S. Buchman

2 months ago | digitalcommons.library.tmc.edu | Aron S. Buchman |Lei Yu |Shahram Oveisgharan |Andrea R. Zammit

BACKGROUND: The interrelationship of parkinsonism, Parkinson's disease (PD) and other Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD) pathologies is unclear. OBJECTIVE: We examined the progression of parkinsonian signs in adults with and without parkinsonism, and their underlying brain pathologies. METHODS: Annual parkinsonian signs were based on a modified Unified Parkinson's Disease Rating Scale.

Aug 13, 2024 | medrxiv.org | Bernard Ng |Julie Schneider |Aron S. Buchman |Ricardo A Vialle

The authors have declared no competing interest. This work has been supported the following National Institute on Aging (NIA) grants: P30AG10161 (DAB), P30AG72975 (JAS), R01AG15819 (DAB), R01AG17917 (DAB), U01AG46152 (PLD, DAB), U01AG61356 (PLD, DAB), R01AG22018 (LLL), U01AG079847 (CG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Aug 4, 2024 | nature.com | Randy Parrish |Aron S. Buchman |Yanling Wang |Michael Epstein

AbstractMultiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for transcriptome-wide association studies (TWAS).

Aug 23, 2023 | nature.com | Shinya Tasaki |Ada Zhang |Aron S. Buchman

AbstractHand drawing, which requires multiple neural systems for planning and controlling sequential movements, is a useful cognitive test for older adults. However, the conventional visual assessment of these drawings only captures limited attributes and overlooks subtle details that could help track cognitive states. Here, we utilized a deep-learning model, PentaMind, to examine cognition-related features from hand-drawn images of intersecting pentagons.