Shan H. Siddiqi

Jan 29, 2024 | nature.com | Shan H. Siddiqi

In military veterans with traumatic brain injury, treatment with ibogaine plus magnesium led to dramatic clinical improvements and a favorable safety profile; further studies with state-of-the art safety monitoring will be crucial to unlocking the potential benefits of this psychedelic compound. The horrors of war have been with us throughout human history, and neuropsychiatric aftereffects have garnered increasing attention in recent years.

Sep 25, 2023 | nature.com | Jacob L. Stubbs |Shan H. Siddiqi |Alexander Cohen |William Thomas Drew |William G. Honer

AbstractSubstance use disorders are associated with neuroimaging abnormalities, but results are heterogeneous across studies and vary across substances, and the causal interpretation of these abnormalities is unknown. We have used network mapping approaches and a functional connectome from a large cohort of healthy participants (n = 1,000) to test whether neuroimaging abnormalities across substance use disorders map to a common brain network.

Jul 31, 2023 | nature.com | Shan H. Siddiqi

AbstractThe principle of targeting brain circuits has drawn increasing attention with the growth of brain stimulation treatments such as transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), and focused ultrasound (FUS). Each of these techniques can effectively treat different neuropsychiatric disorders, but treating any given disorder depends on choosing the right treatment target. Here, we propose a three-phase framework for identifying and modulating these targets.

Apr 6, 2023 | nature.com | Shan H. Siddiqi

Unipolar depression is a common mental disorder that is increasingly treated with neuroimaging-guided therapeutics. Cash et al. use brain connectomics in 57 heterogeneous neuroimaging studies to report meta-analytic brain networks linked to aberrant emotional and cognitive processing in individuals with unipolar depression. Owing to many studies with small sample sizes and flexibility in study designs and analytical methods, the neuroimaging field is experiencing a ‘reproducibility crisis’1.