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Oct 4, 2024 | 
nature.com | Shaoling Peng |Zaixu Cui |Alexander Cohen |Michael Fox
AbstractTask functional magnetic resonance imaging research has generally shielded away from studying individuals due to the low reproducibility. Here, we propose that heterogeneous brain activations across individuals localize to a common network. To test this hypothesis, we use working memory (WM) as our example. First, we showed that discrete-brain-based reproducibility of brain activation during WM across individuals was low.
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Aug 26, 2024 | 00846-8&sz=64)
cell.com | Alexander Cohen |Jennifer R. Keeffe |Sandra E. Dross |Allison J Greaney
Highlights • Pan-sarbecovirus vaccine evaluated in pre-vaccinated monkeys and mice • Mosaic nanoparticles elicited broad antibody responses after COVID-19 vaccinations • Epitope and molecular fate mapping revealed cross-reactive recall responses • Original antigenic sin did not diminish immune responses to a mosaic vaccine Summary Immunization with mosaic-8b (nanoparticles presenting 8 SARS-like betacoronavirus [sarbecovirus] receptor-binding domains [RBDs]) elicits more broadly...
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May 22, 2024 | 
biorxiv.org | Alexander Cohen |Jennifer R. Keeffe |Ariën Schiepers |Sandra E. Dross
AbstractImmunization with mosaic-8b [60-mer nanoparticles presenting 8 SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs)] elicits more broadly cross-reactive antibodies than homotypic SARS-CoV-2 RBD-only nanoparticles and protects against sarbecoviruses.
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May 6, 2024 | 
nature.com | Rory A Hills |Tiong Kit Tan |Alexander Cohen |Jennifer R. Keeffe |Michelle Hill |Madeeha Afzal | +7 more
AbstractDefending against future pandemics requires vaccine platforms that protect across a range of related pathogens. Nanoscale patterning can be used to address this issue. Here, we produce quartets of linked receptor-binding domains (RBDs) from a panel of SARS-like betacoronaviruses, coupled to a computationally designed nanocage through SpyTag/SpyCatcher links.
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Apr 8, 2024 | 
medrxiv.org | Rose Gelineau-Morel |Nomazulu Dlamini |Joel Bruss |Alexander Cohen
The authors have declared no competing interest. This work was supported by NIH NICHD T32HD069038 (RGM), The Auxilium Foundation (ND), NIMH K23MH120510 and the Simons Foundation Autism Research Initiative (AC), NIH NICHD P50 HD103525 (CDS), and NIH NINDS 3R01NS114405 (AB). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Feb 28, 2024 | 
biorxiv.org | Eric Wang |Alexander Cohen |Jennifer R. Keeffe |Luis F. Caldera
AbstractUsing computational methods, we designed 60-mer nanoparticles displaying SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) by (i) creating RBD sequences with 6 mutations in the SARS-COV-2 WA1 RBD that were predicted to retain proper folding and abrogate antibody responses to variable epitopes (mosaic-2COMs; mosaic-5COM), and (ii) selecting 7 natural sarbecovirus RBDs (mosaic-7COM).
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Feb 9, 2024 | 
biorxiv.org | Alexander Cohen |Jennifer R. Keeffe |Ariën Schiepers |Sandra E. Dross
AbstractImmunization with mosaic-8b [60-mer nanoparticles presenting 8 SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs)] elicits more broadly cross-reactive antibodies than homotypic SARS-CoV-2 RBD-only nanoparticles and protects against sarbecoviruses.
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Sep 25, 2023 | 
nature.com | Jacob L. Stubbs |Shan H. Siddiqi |Alexander Cohen |William Thomas Drew |William G. Honer
AbstractSubstance use disorders are associated with neuroimaging abnormalities, but results are heterogeneous across studies and vary across substances, and the causal interpretation of these abnormalities is unknown. We have used network mapping approaches and a functional connectome from a large cohort of healthy participants (n = 1,000) to test whether neuroimaging abnormalities across substance use disorders map to a common brain network.
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Sep 13, 2023 | 
nature.com | Hongbo Zhao |Haitao Dean Deng |Alexander Cohen |Jongwoo Lim |Yiyang Li |Benben Jiang | +2 more
AbstractReaction rates at spatially heterogeneous, unstable interfaces are notoriously difficult to quantify, yet are essential in engineering many chemical systems, such as batteries1 and electrocatalysts2. Experimental characterizations of such materials by operando microscopy produce rich image datasets3,4,5,6, but data-driven methods to learn physics from these images are still lacking because of the complex coupling of reaction kinetics, surface chemistry and phase separation7.
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Jul 3, 2023 | 
jamanetwork.com | Turku Brain |Clinical Neurosciences |Alexander Cohen |Christopher Lin
Key PointsQuestion
Does lesion-related epilepsy map to a brain network? Findings
In this case-control study of lesion locations in patients who either developed epilepsy or did not, lesions associated with epilepsy occurred in multiple heterogenous brain locations.
