Shanghai Institutes

Aug 20, 2024 | cell.com | Zhejiang Province |Westlake Laboratory |Shanghai Institutes

STAR★MethodsREAGENT or RESOURCESOURCEIDENTIFIERAntibodiesanti-NUDT5AbcamCat #ab129172; RRID:AB_11150622anti-Septin8AbcamCat #ab191404Anti-GAPDHCell signaling technologyCat #2118; RRID:AB_561053Bacterial and virus strainsE.

Jun 5, 2024 | academic.oup.com | Shanghai Institutes |Shandong Laboratory |Shuang Li

Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.

Jan 10, 2024 | aacrjournals.org | Shanghai Institutes

Detection of cytoplasmic DNA is an essential biological mechanism that elicits IFN-dependent and immune-related responses. A better understanding of the mechanisms regulating cytoplasmic DNA sensing in tumor cells could help identify immunotherapeutic strategies to improve cancer treatment. Here we identified abundant cytoplasmic DNA accumulated in lung squamous cell carcinoma (LUSC) cells.

Dec 7, 2023 | ehjournal.biomedcentral.com | Shanghai Institutes

The current study utilized data from the UK Biobank, a national multicentre prospective cohort study [22]. Briefly, ~ 0.5 million residents aged 40–69 years between 2006 and 2010 were recruited from the UK National Health Service and living < 25 miles from 1 of the 22 study assessment centres across the UK (England, Wales and Scotland). The baseline summary characteristics can be viewed at the website of UK Biobank (https://biobank.ndph.ox.ac.uk/showcase/).

Oct 30, 2023 | cell.com | Westlake Laboratory |Shanghai Institutes

Highlights•A CBE-TAM-based toolbox enables efficient skipping of most DMD hotspot exons•An unbiased screen discovers novel ESEs in exons 51 and 53 of DMD•CBE-TAM enables multi-exon skipping and correcting dystrophic defects in DMD cellsSummaryDuchenne muscular dystrophy (DMD) is a severe genetic disease caused by the loss of the dystrophin protein. Exon skipping is a promising strategy to treat DMD by restoring truncated dystrophin.