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Jan 20, 2025 | 
bmcmedicine.biomedcentral.com | Sun Yat-sen |Westlake Laboratory
The current analysis was based on the four separate studies, with ZMSC (n = 1781, 2020 survey) and SRRSHS (n = 215) conducted in Zhejiang province, as well as GNHS (n = 4048, 2008-2013 baseline) and GGMP (n = 7009) in Guangdong province (Fig. 1).
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Nov 11, 2024 | 00283-4/fulltext?rss=yes&sz=64)
journalofinfection.com | Westlake Laboratory
KeywordsDelivery ModeInfant HealthMicrobial TransferMaternal MicrobiotaMicrobial RestorationINTRODUCTIONEarly-life gut microbiome colonization plays a crucial role in shaping the metabolic programming and immune system maturation of infants. 1,2 Although debate continues regarding whether microbial colonization begins in utero, 3–6 it is clear that the birthing process is a crucial period for microbial exposure.
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Nov 7, 2024 | 00836-0?rss=yes&sz=64)
cell.com | Westlake Laboratory
Get full text accessLog in, subscribe or purchase for full access. References1. Wei, L. ∙ Yunyuan, X. ∙ Jie, C. ... COLD6-OSM1 module senses chilling for the tolerance via 2', 3'-cAMP signal in riceMolecular Cell. 2024; 84:4224-4238.e92. Li, J. ∙ Zhang, Z. ∙ Chong, K. ... Chilling tolerance in rice: Past and presentJ. Plant Physiol. 2022; 268, 1535763. Jackson, E.K.Discovery and roles of 2′, 3′-cAMP in biological systemsHandb. Exp. Pharmacol. 2017; 238:229-2524. Van Damme, T. ∙ Blancquaert, D. ∙ Couturon, P. ...
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Oct 18, 2024 | 
bmcgenomics.biomedcentral.com | Westlake Laboratory
In this study, we used publicly available Illumina whole-genome sequence data of global cattle breeds, for which the assembly and processing were previously described [34, 35]. The data set was filtered for at least two samples per breed and a mean sequencing depth of ≥ 8x. We further filtered for biallelic SNP variants with a call rate ≥ 95% and genotyping quality (QG) > 20. Samples with a call rate < 75% were excluded.
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Oct 17, 2024 | 
biorxiv.org | Dan Zhao |Xudong Wu |Tom A. Rapoport |Westlake Laboratory
AbstractMisfolded glycoproteins in the endoplasmic reticulum (ER) lumen are translocated into the cytosol and degraded by the proteasome, a conserved process called ER-associated protein degradation (ERAD). In S. cerevisiae, the glycan of these proteins is trimmed by the luminal mannosidase Mnl1 (Htm1) to generate a signal that triggers degradation. Curiously, Mnl1 is permanently associated with protein disulfide isomerase (Pdi1).
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Oct 3, 2024 | 00445-x?rss=yes&sz=64)
cell.com | Westlake Laboratory
Keywordsextracellular lipid dropletsalarmin HMGB1group 2 innate lymphoid cellsneutrophil infiltrationtype 2 inflammationlungGet full text accessLog in, subscribe or purchase for full access. References1. Porsbjerg, C. ∙ Melén, E. ∙ Lehtimäki, L. ... AsthmaLancet. 2023; 401:858-8732. Holgate, S.T. ∙ Wenzel, S. ∙ Postma, D.S. ... AsthmaNat. Rev. Dis. Primers. 2015; 1, 150253. Vivier, E. ∙ Artis, D. ∙ Colonna, M. ... Innate lymphoid cells: 10 years onCell. 2018; 174:1054-10664. Gause, W.C. ∙ Rothlin, C. ∙ Loke, P.
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Sep 23, 2024 | 00510-1?rss=yes&sz=64)
cell.com | Westlake Laboratory
Keywords flexible probe optical waveguide optogenetics implantation mechanical model Introduction The comprehension of brain function and the therapeutic management of neurological disorders highly hinge upon the ongoing development of sophisticated methodologies to interrogate the intricate workings of the nervous system.1,2,3,4,5 In recent decades, optogenetic techniques have emerged as potent instruments for precise and efficacious neural modulation owing to their capacity for...
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Sep 5, 2024 | 00665-8?rss=yes&sz=64)
cell.com | Westlake Laboratory
Get full text accessLog in, subscribe or purchase for full access. References1. Xie, Z. ∙ Zhao, S. ∙ Tu, Y. ... Proteasome resides in and dismantles plant heat stress granules constitutivelyMol. Cell. 2024; 84:3320-3335.e72. Maruri-López, I. ∙ Figueroa, N.E. ∙ Hernández-Sánchez, I.E. ... Plant Stress Granules: Trends and BeyondFront. Plant Sci. 2021; 12, 7226433. Mathieu, C. ∙ Pappu, R.V. ∙ Taylor, J.P.Beyond aggregation: Pathological phase transitions in neurodegenerative diseaseScience. 2020; 370:56-604.
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Aug 30, 2024 | 
cardiab.biomedcentral.com | Sun Yat-sen |Westlake Laboratory
A total of 1180 participants were included in the present study (Fig. S1), with a median age of 69.5 years. 698 (59.2%), 242 (20.5%), and 240 (20.3%) participants were categorized as healthy, mild steatosis, and moderate/severe steatosis, respectively. Participant characteristics according to hepatic steatosis degree were summarized in Table 1 and Table S1.
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Aug 20, 2024 | 00400-2?rss=yes&sz=64)
cell.com | Zhejiang Province |Westlake Laboratory |Shanghai Institutes
STAR★MethodsREAGENT or RESOURCESOURCEIDENTIFIERAntibodiesanti-NUDT5AbcamCat #ab129172; RRID:AB_11150622anti-Septin8AbcamCat #ab191404Anti-GAPDHCell signaling technologyCat #2118; RRID:AB_561053Bacterial and virus strainsE.
