Silvia C. Formenti

Mar 6, 2024 | jamanetwork.com | Lisa Newman |Rachel Martini |Sandra Demaria |Silvia C. Formenti

Population-based breast cancer mortality rates are 40% higher in Black women than White women.1 This disparity is partly explained by Black women having a 2-fold higher incidence of tumors negative for expression of estrogen receptor, progesterone receptor, and ERBB2, ie, triple-negative breast cancer (TNBC).1 Advances in cancer genomics have generated insights regarding immunotherapeutics in breast cancer.

Aug 24, 2023 | nature.com | Nils-Petter Rudqvist |Maud Charpentier |Claire Lhuillier |Erik Wennerberg |Sheila Spada |Xi ZHOU | +2 more

AbstractRadiation therapy (RT) increases tumor response to CTLA-4 inhibition (CTLA4i) in mice and in some patients, yet deep responses are rare. To identify rational combinations of immunotherapy to improve responses we use models of triple negative breast cancer highly resistant to immunotherapy in female mice. We find that CTLA4i promotes the expansion of CD4+ T helper cells, whereas RT enhances T cell clonality and enriches for CD8+ T cells with an exhausted phenotype.