Simone Lanfredini

Oct 18, 2023 | biorxiv.org | Simei Go |Sophie Hughes |Simone Lanfredini |Constantinos Demetriou

AbstractThe immunosuppressive microenvironment in PDAC prevents tumor control but strategies to restore anti-cancer immunology, by increasing CD8 T cell activity, have not been successful. Here we demonstrate how inducing localized physical damage using ionizing radiation (IR) unmasks the benefit of immunotherapy by increasing tissue-resident NK (trNK) cells that support CD8 T activity.