Siu-Shing Wong

Apr 9, 2024 | biorxiv.org | Siu-Shing Wong |Joao Monteiro |Chia-Chun Chang |Min Peng

AbstractMitotic centrosomes form when centrioles recruit large amounts of pericentriolar material (PCM) around themselves. The PCM comprises hundreds of proteins, yet it can assemble and disassemble within minutes, leading to much debate about its physical nature. Here we show that Drosophila Spd-2 fluxes out from centrioles, recruiting Polo and Aurora A to catalyse the assembly of a solid-like Cnn-scaffold and a more liquid-like TACC-scaffold, respectively.

Apr 26, 2023 | biorxiv.org | Siu-Shing Wong |Alan Wainman |Saroj Saurya |Jordan W. Raff

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